Faculty Introduction
About Dr. Bhavya Jha
Faculty profile details will be updated soon.
Qualifications
- Ph.D, March 2019, National Institute of Immunology, DBT, New Delhi, Jawaharlal Nehru University
- M.Sc. in Zoology (specialization in Biochemistry and Molecular Biology), 2013, Banaras Hindu University
Specializations
- Structural and functional characterization of Mycobacterium tuberculosis proteins that are reported essential. Targeting the essential enzymes of Mycobacterium tuberculosis through an integrated approach of structure based and ligand based drug discovery.
Research Interests
- Structural and functional characterization of Mycobacterium tuberculosis proteins that are reported essential. Targeting the essential enzymes of Mycobacterium tuberculosis through an integrated approach of structure based and ligand based drug discovery.
Publications
- Ahmad M, Jha B, Bose S, Tiwari S, Dwivedy A, Kar D, Pal R, Mariadasse R, Parish T, Jeyakanthan J, Vinothkumar KR. Structural snapshots of Mycobacterium tuberculosis enolase reveal dual mode of 2PG binding and its implication in enzyme catalysis. IUCrJ. 2023 Nov 1;10(6). https://doi.org/10.1107/S2052252523008485
- Kumar D, Jha B, Bhatia I, Ashraf A, Dwivedy A, Biswal BK. Characterization of a triazole scaffold compound as an inhibitor of Mycobacterium tuberculosis imidazoleglycerol-phosphate dehydratase. Proteins. 2022 Jan;90(1):3-17. https://doi.org/10.1002/prot.26181
- Dwivedy A, Ashraf A, Jha B, Kumar D, Agarwal N, Biswal BK. De novo histidine biosynthesis protects Mycobacterium tuberculosis from host IFN-γ mediated histidine starvation. Commun Biol. 2021 Mar 25;4(1):410. https://doi.org/10.1038/s42003-021-01926-4
- Jha B, Vyas R, Bhushan J, Sehgal D, Biswal BK. Structural insights into the substrate specificity of SP_0149, the substrate-binding protein of a methionine ABC transporter from Streptococcus pneumoniae. Acta Crystallogr F Struct Biol Commun. 2019 Jul 1;75(Pt 7):520-528. https://doi.org/10.1107/S2053230X19009038
- Dwivedy A, Jha B, Singh KH, Ahmad M, Ashraf A, Kumar D, Biswal BK. Serendipitous crystallization and structure determination of bacterioferritin from Achromobacter. Acta Crystallogr F Struct Biol Commun. 2018 Sep 1;74(Pt 9):558-566. https://doi.org/10.1107/S2053230X18009809
- Jha B, Kumar D, Sharma A, Dwivedy A, Singh R, Biswal BK. Identification and structural characterization of a histidinol phosphate phosphatase from Mycobacterium tuberculosis. J Biol Chem. 2018 Jun 29;293(26):10102-10118. https://doi.org/10.1074/jbc.RA118.002299
- Singh KH, Jha B, Dwivedy A, Choudhary E, N AG, Ashraf A, Arora D, Agarwal N, Biswal BK. Characterization of a secretory hydrolase from Mycobacterium tuberculosis sheds critical insight into host lipid utilization by M. tuberculosis. J Biol Chem. 2017 Jul 7;292(27):11326-11335. https://doi.org/10.1074/jbc.M117.794297
Awards
- Received the prestigious International Union of Crystallography Young Scientist award in December’2018 at Auckland, New Zealand.
- Won poster award at AsCA 2018/CRYSTAL 32 (2018)
- Received DST International Travel Support to attend the AsCA 2018/CRYSTAL 32 at Auckland, New Zealand.
- Received bursary from Immunology foundation to attend the AsCA 2018/CRYSTAL 32 at Auckland, New Zealand.
- Qualified GATE in Life Sciences with 99.67 percentile (2013).
- Qualified NET-JRF in Life Sciences (Dec’12)
- Qualified NET-LS in Life Sciences (June’12)
Responsibilities
- Head of Zoology department, GDMM
- IQAC coordinator of GDMM from July’2020 till date
- Coordinator of IT cell of GDMM
- Member of DRC and RAC of PPU Zoology department
Memberships
- Lifetime member of Indian Science Congress